ANTI-CD55 ANTIBODIES AND RELATED COMPOSITIONS AND METHODS

• Main Authors: WEINBERG ANDREW D, THALHOFER COLIN J, MORRIS NICHOLAS P, MONTLER RYAN D
• Format: Patent
• Language: Chinese; English
• Published: 16.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided are antibodies that specifically bind CD55. Nucleic acids that encode one or both of the variable chain polypeptides of an antibody of the present disclosure are also provided, as are cells that include such nucleic acids. Also provided are compositions that include the antibodies of the present disclosure, including in some instances, pharmaceutical compositions. Methods of making and using the antibodies of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual having a cell proliferative disorder a therapeutically effective amount of an antibody of the present disclosure, where the antibody is administered to the individual to enhance a T cell response to abnormally proliferating cells of the cell proliferative disorder. 提供了特异性结合CD55的抗体。还提供了编码本公开的抗体的可变链多肽之一或两者的核酸，以及包含此类核酸的细胞。还提供了包含本公开的抗体的组合物，在一些情况下包括药物组合物。还提供了制备和使用本公开的抗体的方法。在某些方面，提供了包括向患有细胞增殖性病症的个体施用治疗有效量的本公开的抗体的方法，其中向所述个体施用所述抗体以增强对细胞增殖性病症的异常增殖细胞的T细胞应答。