Cis-platinum derivative-based ursolic acid ligand-containing tetravalent platinum anticancer complex as well as a preparation method and application of the cis-platinum derivative-based ursolic acid ligand-containing tetravalent platinum anticancer complex

• Main Authors: SUN MENGQI, CHEN XIJING, ZHAO DI, BIAN YUEYING, DU QIAN, QIN ZHIYING, LEI SHUYUE
• Format: Patent
• Language: Chinese; English
• Published: 16.11.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

The invention belongs to the field of medicinal chemistry, and particularly relates to a cis-platinum derivative-based ursolic acid ligand-containing tetravalent platinum anticancer complex as well as a preparation method and application of the cis-platinum derivative-based ursolic acid ligand-containing tetravalent platinum anticancer complex. The series of Pt (IV) complexes containing ursolic acid ligands disclosed by the invention take cis-platinum as a basic parent nucleus, ursolic acid derived ligands are introduced into one axial end, and-Cl or-OH groups are introduced into the other axial end; or the ursolic acid derived ligands are introduced into the two axial end; and the raw materials used for preparing the series of Pt (IV) complexes are cheap and easy to obtain, the method is simple and easy to implement, the operation is easy, and the Pt (IV) complexes are suitable for large-scale production. In-vitro experiments show that Pt (IV) complexes US-CIS-CL and US-CIS-OH show very high anti-cancer acti