A PROCESS FOR PREVENTION OF DEGRADATION AND DEGENERATION OF TISSUE USED IN BIOPROSTHESIS

• Main Authors: KOTHWALA DEVESHKUMAR MAHENDRALAL, MINOCHAPRAMOD KUMAR, SHAIKH AMIRHAMZAH MAHMADIQBAL
• Format: Patent
• Language: Chinese; English
• Published: 12.11.2021
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

There is disclosed a process for treatment to avert enzymatic degradation and tissue degeneration of bovine pericardium tissue, used for making bioprosthesis for implant application, comprising the steps of collecting and harvesting raw bovine pericardial tissue; chemically cross-linking the rinsed tissue to generate fixed tissue; laser cutting said fixed tissue to produce tissue leaflet; chemically treating said tissue leaflet with AAS; chemically sterilising and storing the fixed bovine pericardium tissue to maintain the structural integrity and characteristics; and wherein all the above steps are carried out in a low-oxygen and controlled temperature environment. 本发明公开了一种防止牛心包组织的酶促降解和组织变性的处理方法，用于制造用于植入物的生物假体，该方法包括以下步骤：收集和采获生牛心包组织；将冲洗过的组织化学交联以产生固定的组织；激光切割所述固定的组织以产生组织小叶；用AAS化学处理所述组织小叶；对固定的牛心包组织进行化学灭菌和保存，以保持结构的完整性和特性；并且其中上述所有步骤均在低氧受控温度环境下进行。