Application of miriplatin lipidosome to resistance to drug-resistant tumors

• Main Authors: XIA GUIMIN, WANG XIAOWEI, WANG MENGYAN, QIU YUHAN, SHAO RONGGUANG, ZHAO WULI
• Format: Patent
• Language: Chinese; English
• Published: 12.11.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of medicines, and relates to an application of miriplatin lipidosome to resistance to drug resistance. The miriplatin liposome is found to be capable of reversing natural and acquired drug resistance of tumor cells to tumor drugs. Furthermore, it is found that the miriplatin liposome has a remarkable killing effect on tumor stem cells of a tumor recurrence root, inhibits metastasis and tumor recurrence, provides a good direction for thorough treatment of tumors, and is beneficial to more tumor patients and has important clinical application value. 本发明属于药物领域，涉及米铂脂质体在抗耐药性中的应用。本发明发现米铂脂质体能够逆转，肿瘤细胞对肿瘤药物的天然和获得性耐药。进一步发现其对肿瘤复发根源的肿瘤干细胞具有显著杀伤作用，抑制转移和肿瘤复发，对肿瘤的彻底治疗提供了一个很好的方向，造益于更多肿瘤患者，具有重要的临床应用价值。