Betaine salicylic acid eutectic crystal as well as preparation method and application thereof

• Main Authors: HAN ZHIXUAN, GAN RUIJING, WANG TIANXIAO, LI XUEYUN, WU CHENGYU, ZHANG JIAHENG, WANG ZHENYUAN
• Format: Patent
• Language: Chinese; English
• Published: 09.11.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The invention provides a betaine salicylic acid eutectic crystal as well as a preparation method and application thereof, and relates to the technical field of medicines and cosmetics. The invention relates to a betaine salicylic acid eutectic crystal. The betaine salicylic acid eutectic crystal is an orthorhombic system; the space group is Pbca; the cell parameters are as follows: a=10.2107(8) Angstroms, b=10.7746(8) Angstroms, c=22.5314(17) Angstroms, alpha = beta = gamma = 90 degrees, and Z = 8; and the cell volume V is equal to 2478.8(3) Angstrom . The betaine and salicylic acid eutectic crystal provided by the invention can improve the irritation problem of betaine salicylate. 本发明提供一种甜菜碱水杨酸共晶及其制备方法和应用，涉及医药、化妆品技术领域。一种甜菜碱水杨酸共晶，所述甜菜碱水杨酸共晶为斜方晶系，空间群为Pbca，晶胞参数为α＝β＝γ＝90°，Z＝8，晶胞体积本发明提供的甜菜碱水杨酸共晶，能够改善甜菜碱水杨酸盐的刺激性问题。