Adult Onset Still' s Disease biomarker, diagnostic reagent and application thereof

• Main Authors: ZHANG BO, ZHAO MING, LI YUWEI, RAO SHIJIA, LU QIANJIN
• Format: Patent
• Language: Chinese; English
• Published: 05.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention discloses a DNA methylation marker of Adult Onset Still' s Disease (AOSD), a diagnostic reagent and application thereof. The DNA methylation marker comprises one or more of six methylation sites: chr11:114167495, chr1:198568084, chr6:35654359, chr6:35654363, chr13:113327910 and chr6:139794538. The invention utilizes specific DNA methylation sites as molecular markers for the first time to conduct auxiliary screening on AOSD patients and healthy people, Rheumatoid Arthritis (RA), Sepsis (Sepsis), drug rash (DrugEruption), and T cell lymphoma (TcellLymphoma) patients, opens up a new way and way for diagnosis in the field, needs few blood samples, is convenient and easy to develop, and has very good application prospects. 本发明公开了成人still's病(Adult Onset Still's Disease,AOSD)的DNA甲基化标记物、诊断试剂及其应用。包括6个甲基化位点：chr11:114167495、chr1:198568084、chr6:35654359、chr6:35654363、chr13:113327910、chr6:139794538的一个或多个。本发明首次利用特定的DNA甲基化位点作为分子标记对成人still病患者与健康人、类风湿关节炎(Rheumatoid Arthritis,RA)、脓毒血症(Sepsis)、药疹(DrugEruption)、T细胞