Modified algin as well as preparation method and application of modified algin in preparation of medicine for promoting gastrointestinal motility

• Main Authors: SUN JIMIN, LIU XUE, LIU CHANGHENG, JIA AIRONG, ZHANG MIANSONG, CUI TINGTING, SHI YAPING, XU ZHENLU
• Format: Patent
• Language: Chinese; English
• Published: 05.11.2021
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses modified algin and a preparation method thereof and application of the modified algin in preparation of a medicine for promoting gastrointestinal motility. According to the invention, kelp is used as a raw material, water extraction is firstly carried out, and then acid precipitation and alkali dissolution are carried out to obtain algin. Early stage test results show that the obtained algin does not have the biological activity in promoting gastrointestinal motility of mice with constipation, so the algin is subjected to heating degradation under an acidic condition so as to obtain the modified algin; and experiments show that the modified algin has remarkable biological activity in promoting gastrointestinal motility of the mice with constipation. 本发明公开了改性褐藻胶及制备方法与其在制备促进胃肠蠕动药物中的应用，本发明以海带为原料，先采用水提取，再经过酸沉碱溶获得褐藻胶；通过前期试验发现上述获得的褐藻胶没有促进便秘小鼠胃肠蠕动的生物活性，因而将褐藻胶在酸性条件下进行加热降解获得改性褐藻胶。经过实验发现，该改性褐藻胶具有显著的促进便秘小鼠胃肠蠕动的生物活性。