Chimeric antigen receptors targeting B-cell maturation antigen and uses thereof

• Main Authors: SMITH ERIC L, BRENTJENS RENIER J, LIU CHEN
• Format: Patent
• Language: Chinese; English
• Published: 05.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma, and relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BMCA), and immunoresponsive cells comprising such CARs. The presently disclosed BMC A- specific CARs have enhanced immune-activating properties, including anti-tumor activity. 本发明公开的主题在于提供用于治疗多发性骨髓瘤的方法和组合物。其涉及与B-细胞成熟抗原(BMCA)特异性结合的嵌合抗原受体(CAR)以及包括该CAR的免疫应答细胞。本发明公开的BMC A-特异性CAR具有提高的包括抗肿瘤活性的免疫激活特性。