Anti-human SEMA4D antibody as well as preparation method and application thereof

• Main Authors: WANG YING, LUO SHAOXIANG, GAO XIA, WANG JING, YIN TINGZI, YUAN WENWEN, YI WANGXUE, ZHANG ZHEN, YU QIAN
• Format: Patent
• Language: Chinese; English
• Published: 02.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to the technical field of biology, in particular to an anti-human SEMA4D antibody and a preparation method and application thereof. The anti-human SEMA4D antibody can be used for specifically recognizing an SEMA4D protein; the anti-human SEMA4D antibody comprises a first antibody or a second antibody; the first antibody comprises any one of amino acid sequences as shown in SEQ ID NO: 1-SEQ ID NO: 37, the second antibody sequence meets at least one of the following conditions: a heavy chain amino acid sequence comprises any one of amino acid sequences as shown in SEQ ID NO: 38-SEQ ID NO: 42, a light chain amino acid sequence comprises any one of amino acid sequences as shown in SEQ ID NO: 43-SEQ ID NO: 47, and a plurality of anti-human SEMA4D antibodies with higher affinity are obtained. An early detection and diagnosis marker and a treatment target are provided, and a basis is provided for combined antibody medication and tumor control. 本申请涉及生物技术领域，尤其涉及抗人SEMA4D抗体及其制备方法和应用。所述抗人SEMA4D抗体能特异