Preparation method of 2-phenyl quinazolinone compound

• Main Authors: WEN-SI MIAOMIAO, LIU QIXING, ZHOU HAIFENG, CUI XIAOFENG, ZHAO RONGRONG
• Format: Patent
• Language: Chinese; English
• Published: 29.10.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a preparation method of a 2-phenyl quinazolinone compound. The specific structure of the 2-phenyl quinazolinone compound is shown in a formula II. According to the method, a 2-(benzylamino) benzamide compound (I) is used as a raw material for reaction of the experimental model, and an elemental iodine catalyst and a solvent are added into a reaction reagent to obtain a target product (II); and the innovation point of the method is as follows: the easily available 2-(benzylamino) benzamide is used as the raw material for the first time, a metal-free catalyst is used under mild conditions, the 2-phenyl quinazolinone compound is obtained with higher yield, and the method has the advantages of green synthesis such as step economy and atom economy. 本发明涉及2-苯基喹唑啉酮类化合物的制备方法，具体结构如II所示。该方法以2-(苄基氨基)苯甲酰胺类化合物(I)为该实验模型反应的原料，加入单质碘催化剂及溶剂在反应试剂中，得到目标产物(II)；本发明的创新点在于首次以易得的2-(苄基氨基)苯甲酰胺为原料，在温和的条件下使用无金属催化剂，以较高的产率得到2-苯基喹唑啉酮类化合物，具有步骤经济性、原子经济性等绿色合成的优点。