DEVICES AND SYSTEMS WITH INTEGRATED ELECTRODES OR OPTICAL ELEMENTS FOR MONITORING CELL CULTURES AND RELATED METHODS

• Main Authors: GRIER JR R D, PREYER AMANDA JERVIS, CLEMENTS MICHAEL ANTONY, ROSS JAMES DAVID, WILLSIE ANDREW, BROWN EDGAR A, MILLARD DANIEL CHRISTOPHER, CLEMENTS ISAAC PERRY, O'BRIEN THOMAS J, SULLIVAN DENISE DANIELLE
• Format: Patent
• Language: Chinese; English
• Published: 22.10.2021
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions. 本文描述了用于集成到细胞培养物培养箱中