5T4 SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC COMPOSITIONS THEREOF

• Main Authors: TIMMER JOHN C, WILLIS KATELYN M, BARNES SYDNEY A, PANDIT RAJAY A, SANABRIA ANGELICA N, ECKELMAN BRENDAN P, JACKSON RUTGER H, KAPLAN MICHAEL D, HAERR MARGARET E
• Format: Patent
• Language: Chinese; English
• Published: 19.10.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are binding polypeptides that specifically bind 5T4. More specifically, provided herein are fusion proteins, including multivalent and/or multispecific constructs and chimeric antigen receptors, that bind 5T4. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors and cells thereof, and methods of use and uses of the provided 5T4 binding polypeptides for treating diseases and conditions, such as cancer. 本发明提供特异性结合5T4的结合多肽。更具体言之，本文提供结合5T4的融合蛋白，其包括多价和/或多特异性构建体和嵌合抗原受体。也提供含有所述多肽的医药组合物；编码所述多肽的核酸分子以及其载体和细胞；以及所提供的5T4结合多肽用于治疗诸如癌症的疾病和病状的使用方法和用途。