CRF1 RECEPTOR ANTAGONIST, PHARMACEUTICAL FORMULATIONS AND SOLID FORMS THEREOF FOR THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA

• Main Authors: PARKS STACY, DOWNING KRISTIE M, SAYERS BRIAN, IYOHA KINGSLEY, TAYLOR GRAEME, STIRN SCOTT, GIRI NAGDEEP, VICKERY ANTHONY D, ZHANG XIAOPING, CHARLIER ANNE, LOEWEN GORDON RAPHAEL, MEHTON GURVINDER SINGH, FARBER ROBERT H, CHAN JEAN L, NGWENYA-JONES AYANDA, COSTA CHRISTINA MARIE
• Format: Patent
• Language: Chinese; English
• Published: 19.10.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided are methods related to treating congenital adrenal hyperplasia in a subject in need thereof comprising administering 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Formula 1), or a pharmaceutically acceptable salt thereof. Further provided are pharmaceutical formulations and solid forms of 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(lS)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-mcthyl-N-prop-2-ynyl-1,3-thiazol-2-amine, or a pharmaceutically acceptable salt thereof, and their use in the treatment of congenital adrenal hyperplasia (CAH). 提供了与治疗有需要的个体中的先天性肾上腺皮质增生症相关的方法，所述方法包括施用4-(2-氯-4-甲氧基-5-甲基苯基)-N-[(1S)-2-环丙基-1-(3-氟-4-甲基苯基)乙基]-5-甲基-N-丙-2-炔基-1,3-噻唑-2-胺(式I)或其药物可接受的盐。进一步提供了4-(2-氯-4-甲氧基-5-甲基苯基)-N-[(1S)-2-环丙基-1-(3-氟-4-甲基苯基)乙基]-5-甲基-N-丙-2-炔基-1,3-噻唑-2-胺或其药物可接受的盐的药物制剂和固体形式及其在治疗先天性肾上腺皮质增生症(CAH)中的用途。