METHODS FOR DETECTING AND QUANTIFYING MEMBRANE-ASSOCIATED PROTEINS ON EXTRACELLULAR VESICLES

The present disclosure provides assays for the detection and/or quantification of membrane-associated proteins, e.g., circulating CD20 (cCD20), incorporating an extracellular vesicle-based calibrator comprising the membrane-associated tumor antigen as well as the use of such assays in the detection...

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Bibliographic Details
Main Authors BRADY ANN THERESE, SUN YONGLIAN, KOERBER JAMES T, WANG XIANGDAN, PHAN MINH M N, GUPTA VISHAKHA
Format Patent
LanguageChinese
English
Published 01.10.2021
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The present disclosure provides assays for the detection and/or quantification of membrane-associated proteins, e.g., circulating CD20 (cCD20), incorporating an extracellular vesicle-based calibrator comprising the membrane-associated tumor antigen as well as the use of such assays in the detection and treatment of hyperproliferative disorders. 本公开提供了用于检测和/或定量膜相关蛋白(例如循环CD20(cCD20))的测定法，所述测定法将包含膜相关肿瘤抗原的基于细胞外囊泡的校准物纳入其中，以及提供了此类测定法在过度增殖性病症的检测和治疗中的用途。
Bibliography:Application Number: CN202080016733