Naphtho gamma-pyrone compounds in preparation of anti-helicobacter pylori drugs or preventive health products

• Main Authors: YAO XINSHENG, JIA JIA, DING WENJUAN, DONG ZHITONG, XUE YAXIN, GOU XIAOSHUANG, HONG KUI, TANG JINSHAN, BI HONGKAI
• Format: Patent
• Language: Chinese; English
• Published: 28.09.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The invention discloses application of naphtho gamma-pyrone compounds in preparation of anti-helicobacter pylori drugs or preventive health products. The invention provides a marine fungus named Aspergillus sp.DM94, and the preservation number is CCTCC NO: M 20191003. The naphtho gamma-pyrone compounds are extracted and separated from a fermentation culture of the marine fungus by utilizing polarity difference of naphtho gamma-pyrone. The method is simple and convenient to operate, high in extraction yield, high in product purity and suitable for large-scale production. In-vitro antibacterial experiments show that the naphtho gamma-pyrone compounds have good in-vitro antibacterial activity, the MIC value of the naphtho gamma-pyrone compounds is 4-64 [mu] g/mL aiming at a helicobacter pylori standard strain G27 as well as levofloxacin, clarithromycin and metronidazole multi-drug-resistant strains HP159, and the naphtho gamma-pyrone compounds can be used for preparing antibacterial drugs and preventive health f