Diagnosis and therapy of cancer involving cancer stem cells

• Main Authors: HAECKER SABINE, VALTER KORDEN, YAKOBS SHTEFAN, VAGNER MAJKE, SAHIN UGUR, MARIA KREUZBERG, TURECI OZLEM
• Format: Patent
• Language: Chinese; English
• Published: 17.09.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Diagnosis and therapy of cancer involving cancer stem cells. The present invention provides methods for diagnosis or therapy of cancer diseases involving cancer stem cells, the methods comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient. 本申请涉及癌症干细胞的癌症的诊断与治疗。本发明提供了用于诊断或治疗涉及癌症干细胞之癌症疾病的方法，其包括靶向CLDN6。特别地，本发明提供了确定癌症干细胞的方法，其包括检测表达CLDN6的细胞。此外，本发明提供了治疗或预防癌症的方法，其包括通过向癌症患者施用能够与CLDN6结合的抗体来抑制和/或消除癌症干细胞。