FcRn antibodies and methods of use thereof

• Main Authors: KEHRY MARILYN, LING LEONA E, JAMES MEADOR III, KING DAVID J, MANNING ANTHONY, ROY SUGATA
• Format: Patent
• Language: Chinese; English
• Published: 14.09.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to FCRN antibodies and methods of use thereof. The present invention features antibodies that have high binding affinity to human neonatal Fc receptor (FcRn). These anti-FcRn antibodies are useful, e.g., to promote clearance of autoantibodies in a subject, to suppress antigen presentation in a subject, to block an immune response, e.g., block an immune complex-based activation of the immune response in a subject, and to treat immunological diseases (e.g., autoimmune diseases) in a subject. 本发明涉及FCRN抗体及其使用方法。本发明的特征在于对人类新生儿Fc受体(FcRn)具有高结合亲和力的抗体。这些抗-FcRn抗体可用于例如促进受试者中自身抗体的清除，抑制受试者中的抗原呈递，阻断受试者中免疫应答例如阻断基于免疫复合体的免疫应答激活，以及治疗受试者中的免疫性疾病(例如自身免疫疾病)。