Preparation method of 2-amino-6-chloro-4-nitrophenol

The invention relates to a preparation method of 2-amino-6-chloro-4-nitrophenol. The preparation method comprises the following steps: (1) chlorination reaction: with 2-amino-4-nitrophenol as a raw material, adding a catalyst and a chlorination reagent into an organic solvent, and conducting reactin...

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Bibliographic Details
Main Authors GU FENGLEI, PAN ZHIJUN, DAI XUEMING, LOU JIAWEI, HE ZHIQING
Format Patent
LanguageChinese
English
Published 10.09.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a preparation method of 2-amino-6-chloro-4-nitrophenol. The preparation method comprises the following steps: (1) chlorination reaction: with 2-amino-4-nitrophenol as a raw material, adding a catalyst and a chlorination reagent into an organic solvent, and conducting reacting at a certain temperature to obtain a chlorination reaction solution; (2) solvent recovery: after the reaction is finished, carrying out reduced pressure distillation to recover the solvent, after 70-80% of the solvent is evaporated off, supplementing water, and continuing to recover the residual solvent; and (3) purification: after the solvent is recovered, adjusting a pH value to reach a weakly alkaline, conducting heating until materials are completely dissolved, performing recrystallizing, carrying out filtering, acidizing an obtained solid, and performing cooling to obtain the 2-amino-6-chloro-4-nitrophenol. According to the invention, a process is simple, the post-treatment of a product is simple and conveni
Bibliography:Application Number: CN202110637239