Composition and methods for inhibition of CD279 interaction

Disclosed herein are a composition and method for inhibition and/or interference of the interaction between (1) programmed death-1 protein (also referred to as CD279) and (2) a programmed death ligand 1(PD-L1), and/or a program death ligand 2 (PD-L2). In addition, the invention also discloses a comp...

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Bibliographic Details
Main Authors LEE YI FANG, WILLIAM JIA, BU XUEXIAN
Format Patent
LanguageChinese
English
Published 07.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are a composition and method for inhibition and/or interference of the interaction between (1) programmed death-1 protein (also referred to as CD279) and (2) a programmed death ligand 1(PD-L1), and/or a program death ligand 2 (PD-L2). In addition, the invention also discloses a composition and method for increasing the IL-2 level in cells, and a method and composition for preventing, treating or improving the effects of cancer in a subject. 本文披露了用于抑制和/或干扰(1)程序性死亡-1蛋白(也称作CD279)和(2)程序性死亡配体1(PD-L1)和/或程序性死亡配体2(PD-L2)之间的相互作用的方法和组合物。另外，本文还披露了用于增加细胞中IL-2水平的方法和组合物，以及用于预防、治疗或改善受试者中癌症的影响的方法和组合物。
Bibliography:Application Number: CN202110491174