Gene delivery system for targeting breast cancer tumor, and preparation method and application thereof

• Main Authors: GUO FENGJUAN, ZHU YAO, HE TIANZHEN, XU JINFENG, LIU YINGYING, LAI XIAOSHU, SU LILI
• Format: Patent
• Language: Chinese; English
• Published: 07.09.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses a gene delivery system for targeting breast cancer tumor, and a preparation method and application thereof. The gene delivery system for targeting breast cancer tumor comprises a gene delivery vector for targeting breast cancer tumor and a CPTA1-shRNA recombinant plasmid loaded on the delivery vector. The invention realizes the targeted enrichment of CPT1A-shRNA in breast cancer tumor by transporting and transfecting CPT1A-shRNA, increases the enrichment degree of CPT1A-shRNA in target tissue, and improves the therapeutic effect of breast cancer therapeutic gene. 本申请公开了了一种靶向乳腺癌肿瘤的基因递送系统及其制备方法和应用，所述靶向乳腺癌肿瘤的基因递送系统包括靶向乳腺癌肿瘤的基因递送载体以及负载于所述递送载体上的CPTA1-shRNA重组质粒。本申请的通过对CPT1A-shRNA运输和转染，实现了CPT1A-shRNA在乳腺癌肿瘤的靶向富集，增加了CPT1A-shRNA在靶组织的富集程度，提高了乳腺癌治疗基因的治疗效果。