Bacterium and MOF-based carrier hybrid material as well as preparation method and application thereof

• Main Authors: CHEN WEIHAI, LIANG JUNLONG, ZHANG XIANZHENG, WANG JIAWEI, LUO GUOFENG
• Format: Patent
• Language: Chinese; English
• Published: 07.09.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a bacterium and MOF-based carrier hybrid material as well as a preparation method and application thereof, and the method comprises the following steps: loading a therapeutic agent on MOF nanoparticles to obtain a chemotherapeutic drug loaded MOF carrier; wrapping hyaluronic acid on the MOF carrier loaded with the chemotherapeutic drug to obtain an MOF carrier with electronegative surface; modifying the surface of shewanella with polyallylamine hydrochloride to obtain a shewanella solution with electropositive surface; and combining the MOF carrier with electronegative surface and the shewanella solution with electropositive surface through electrostatic interaction to obtain the bacterium and MOF-based carrier hybrid material. The bacterium and MOF-based carrier hybrid material is high in accuracy in anti-tumor treatment, can be used for multi-mode combined treatment, not only combines the advantages of each single therapy, but also can make up the respective defects, thereby generati