Bacterium and MOF-based carrier hybrid material as well as preparation method and application thereof
The invention discloses a bacterium and MOF-based carrier hybrid material as well as a preparation method and application thereof, and the method comprises the following steps: loading a therapeutic agent on MOF nanoparticles to obtain a chemotherapeutic drug loaded MOF carrier; wrapping hyaluronic...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
07.09.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a bacterium and MOF-based carrier hybrid material as well as a preparation method and application thereof, and the method comprises the following steps: loading a therapeutic agent on MOF nanoparticles to obtain a chemotherapeutic drug loaded MOF carrier; wrapping hyaluronic acid on the MOF carrier loaded with the chemotherapeutic drug to obtain an MOF carrier with electronegative surface; modifying the surface of shewanella with polyallylamine hydrochloride to obtain a shewanella solution with electropositive surface; and combining the MOF carrier with electronegative surface and the shewanella solution with electropositive surface through electrostatic interaction to obtain the bacterium and MOF-based carrier hybrid material. The bacterium and MOF-based carrier hybrid material is high in accuracy in anti-tumor treatment, can be used for multi-mode combined treatment, not only combines the advantages of each single therapy, but also can make up the respective defects, thereby generati |
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Bibliography: | Application Number: CN202110562765 |