Esomeprazole magnesium (Nexium) sustained-release preparation and preparation method thereof

• Main Authors: GANNISHABA MANZHUNATE, WAYIBAFU PANDITELUO DESHIMUKE, YINGDELAJITE SUBASHI KATEKE, LIAO ZUHUA
• Format: Patent
• Language: Chinese; English
• Published: 07.09.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of medicines, and particularly relates to an esomeprazole magnesium (Nexium) sustained-release preparation and a preparation method thereof. The preparation method comprises the following steps of: preparing esomeprazole magnesium (Nexium) pellets or granules, filling hydroxypropyl methyl cellulose capsules with the esomeprazole magnesium (Nexium) pellets or granules, and then coating. Compared with the traditional esomeprazole magnesium (Nexium) sustained-release preparation, the preparation method has the advantages that a series of complex steps such as preparation of a medicine suspension, coating of a medicine layer on a sucrose pellet core, preparation of a barrier layer suspension, coating of a protective/barrier layer, preparation of an enteric-coated layer dispersion liquid and coating of an enteric-coated layer are omitted, a shear barrier protective layer is not needed, repeated pellet coating is avoided, time and cost can be saved, a sealing step is eli