CHOLIX-DERIVED CARRIERS FOR ORAL DELIVERY OF HETEROLOGOUS PAYLOAD

• Main Authors: LAURENT FLORIANE, LIU KEYI, MRSNY RANDALL J, MAHMOOD TAHIR, OLSON CHARLES, HUNTER THOMAS CARL, TAVERNER ALISTAIR, FENG WEIJUN, POSTLETHWAITE SALLY
• Format: Patent
• Language: Chinese; English
• Published: 03.09.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure provides delivery constructs comprising a carrier coupled to a heterologous payload, wherein coupling of the carrier to the payload can result in transportation of the payload (e.g., a therapeutic payload) into and/or across intact polarized epithelial cells (e.g., epithelial cells of the gut of a mammal). The delivery construct can be part of a pharmaceutical composition that can be orally administered to a subject to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases or autoimmune diseases. 本公开提供了递送构建体，其包含与异源有效载荷偶联的携带体，其中所述携带体与所述有效载荷的偶联可以导致所述有效载荷(例如，治疗性有效载荷)被转运到完整的极化上皮细胞(例如，哺乳动物的肠上皮细胞)中和/或转运穿过所述细胞。所述递送构建体可以是药物组合物的部分，所述药物组合物可以口服施用给受试者，以提供用于治疗例如炎性疾病或自身免疫疾病的改进的有效疗法。