Substituted amide derivative, and composition and application thereof

• Main Authors: XING QINGFENG, LI HUANYIN, AI YIXIN, WANG YIHAN, ZHAO JIUYANG
• Format: Patent
• Language: Chinese; English
• Published: 03.09.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a substituted amide derivative, a composition containing the compound, and application of the substituted amide derivative. The substituted amide derivative is a compound shown in a formula (I) or a tautomer, a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a hydrate or a solvate of the compound. The compound and the composition thereof can be used for treating and/or preventing wild and/or mutant EGFR and/or HER2 kinase mediated tumors. 本发明提供了一种取代的酰胺衍生物及包含该化合物的组合物及其用途，所述的取代的酰胺衍生物为式(I)所示化合物或其互变异构体、立体异构体、前药、晶型、药学上可接受的盐、水合物或溶剂合物。本发明化合物及其组合物可用于治疗和/或预防野生的和/或突变的EGFR和/或HER2激酶介导的肿瘤。