9-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE

• Main Authors: SWAMINATHAN UMA, WANG HOWARD, LARSEN MATTHEW A, PAN JIANPING, DENG QIAOLIN, MANSOOR UMAR FARUK, LIU KUN, CUMMING JARED, LIU PINGLI, DEMONG DUANE, ALLI AZAAM, PLUMMER CHRISTOPHER W, SATHER AARON, ZHANG YONGLIAN, GRAHAM THOMAS H, HOOVER ANDREW J, HENNESSY ELISABETH
• Format: Patent
• Language: Chinese; English
• Published: 31.08.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

In its many embodiments, the present invention provides certain 9-substituted amino triazolo quinazoline compounds of the structural Formula (I): (I), and pharmaceutically acceptable salts thereof, wherein, ring A, R1 and R2 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor. 在其许多实施方案中，本发明提供了某些结构式(I)的9-取代的氨基三唑并喹唑啉化合物：(I)，及其药学上可接受的盐(其中，环A、R1和R2如本文所定义)，包含一种或多种这样的化合物(单独和与一种或多种其它治疗活性剂组合)的药物组合物以及它们的制备和使用(单独和与其它治疗剂组合地，作为A2a和/或A2b受体的拮抗剂和在至少部分地由腺苷A2a受体和/或腺苷A2b受体所介导的各种疾病、状况或病症的治疗中)方法。