Preparation method of 2-amino-1, 3, 4-oxadiazole compound and prepared compound

• Main Authors: LONG BINGYU, GAN ZONGJIE, TIAN BINGHUA, YU YU
• Format: Patent
• Language: Chinese; English
• Published: 27.08.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of medical chemistry, and particularly relates to a preparation method of a 2-amino-1, 3, 4-oxadiazole compound and the compound prepared by the preparation method. According to the method, the 1, 3, 4-oxadiazole compound is prepared by taking the isothiocyanate compound and the benzoyl hydrazine compound as raw materials and taking the mild, cheap and easily available potassium hydrogen sulfate as the catalyst, so that not only is the use of harmful reagents with relatively strong corrosivity such as sulfuric acid avoided, but also the yield can be up to 85%, and the method is convenient in post-treatment and suitable for industrial production. 本发明属于医药化学领域，具体涉及一种2-氨基-1,3,4-噁二唑类化合物的制备方法及其制备的化合物。所述方法以异硫氰酸酯类化合物和苯甲酰肼类化合物为原料，以温和、便宜易得的硫酸氢钾为催化剂，制备1,3,4-噁二唑类化合物，不仅避免了硫酸等腐蚀性较强的有害试剂的使用，同时收率可高达85％，后处理方便，适合工业化生产。