APPLICATION OF CIRCULATING TFPI-2 (TISSUE FACTOR PATHWAY INHIBITOR 2) IN THE ASSESSMENT OF ATRIAL FIBRILLATION AND ANTICOAGULATION THERAPY

• Main Authors: ULRICH SCHOTTEN, ROLNY VINZENT, WIENHUES-THELEN URSULA-HENRIKE, ZIGLER ARI, KASTNER PETER, DIETRICH MANUEL
• Format: Patent
• Language: Chinese; English
• Published: 24.08.2021
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of TFPI-2 in a sample from the subject, and comparing the amount of TFPI-2 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for assessing anticoagulation therapy and to methods for predicting the risk of stroke of a subject. Said methods are based on the determination of the amount of TFPI-2 in a sample from the subject. 本发明涉及一种用于评定受试者心房颤动的方法，所述方法包括以下步骤：测定来自所述受试者的样品中的TFPI-2的量，以及将所述TFPI-2的量与参考量进行比较，借此评定心房颤动。此外，本发明涉及用于评定抗凝治疗的方法以及用于预测受试者的脑卒中风险的方法。所述方法是基于所述对来自所述受试者的样品中的TFPI-2的量的测定。