NON-AQUEOUS CHEMOTHERAPEUTIC SUSPENSIONS FOR ORAL DOSAGE

• Main Authors: PATEL VIPUL, UMRETHIA MANISH, MANDAL JAYANTA, MEHTA SAMEEP
• Format: Patent
• Language: Chinese; English
• Published: 24.08.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses pharmaceutical compositions comprising oil as a vehicle, a suspending agent, and a surfactant are disclosed to be used in conjunction with active pharmaceutical ingredients which are water soluble or insoluble, or which are sensitive to water but insoluble in oil. Such active pharmaceutical ingredients may include temozolomide, lenalidomide, Oxaliplatin, Cisplatin, Carboplatin, 5-fluorouracil, irinotecan, topotecan, cyclophosphamide, doxorubicin, vincristine, vinblastine, Melphalan, Chlorambucil, Dacarbazine, Daunorubicin, Epirubicin, Mitoxantrone, Etoposide, Teniposide, Azacitidine, Cytarabine, Gemcitabine, vinoralbine, Pemetrexed, a derivative thereof, or a combination thereof. The pharmaceutical compositions may be administered as an oral suspension. Other embodiments are directed towards methods of using and methods of making such formulations. 公开了包含油作为载体，悬浮剂和表面活性剂的药物组合物，其与可溶于水、不溶于水或对水敏感但不溶于油的活性药物成分一起使用。这些活性药物成分可包括替莫唑胺、来那度胺、奥沙利铂、顺铂、卡铂、5-氟尿嘧啶、伊立替康、拓扑替康、环磷酰胺、阿霉素、长春新碱、长春花碱、美法仑、苯丁酸氮芥、达