MULTIVALENT REGULATORY T CELL MODULATORS

• Main Authors: NAGARAJAN NIRANJANA, GREVE JEFFREY, KING JOAN
• Format: Patent
• Language: Chinese; English
• Published: 20.08.2021
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

This disclosure provides compounds that contain an IL-2 receptor-binding domain and an ST2-binding domain, e.g. an antibody or fragment thereof that specifically binds ST2. The methods described in the present disclosure provide for a method for treating a condition by administering to a subject in need thereof a therapeutically-effective amount of a compound containing an IL-2 receptor-binding domain and an ST2-binding domain. 本公开内容提供了包含IL-2受体结合结构域和ST2结合结构域的化合物，例如，特异性结合ST2的抗体或其片段。在本公开内容中描述的方法提供了一种通过向有需要的受试者施用治疗有效量的包含IL-2受体结合结构域和ST2-结合结构域的化合物来治疗病况的方法。