COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS

• Main Authors: ZASK ARIE, STOCKWELL BRENT R, DANIELS JACOB, TAN HARRY
• Format: Patent
• Language: Chinese; English
• Published: 20.08.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure provides, inter alia, a compound having the structure (1). Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject. 本公开内容尤其提供了具有结构(1)的化合物：还提供了组合物，其含有药学上可接受的载体和根据本公开内容的一种或多种化合物。进一步提供了用于在受试者中治疗或改善兴奋性神经毒性障碍的影响的方法，在受试者中调节铁死亡的方法，减少细胞中的活性氧类别(ROS)的方法，用于治疗或改善神经变性疾病的影响的方法，用于在经历放射疗法和/或免疫疗法的受试者中减轻副作用的方法，和用于在受试者中治疗或改善与铁死亡有关的感染的影响的方法。