DOSING REGIMEN AND PHARMACEUTICAL COMBINATION COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES

• Main Authors: CAMERON JOHN SCOTT, PETRUZZELLI LILLI MARY, FORSETH RY ROGER, BONAZZI SIMONE, KINYAMU-AKUNDA JACQUELINE, D'HENNEZEL EVA MARIE GENEVIEVE, LIANG GUIQING, HAINZL DOMINIK JOHANNES, CRYSTAL ADAM, DRANOFF GLENN
• Format: Patent
• Language: Chinese; English
• Published: 17.08.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to dosing regimens, formulations, and combinations comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione compounds or pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease, for example, the treatment of cancers. 本披露涉及包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮化合物或包含含有所述化合物的药物组合物的给药方案、配制品和组合；以及在IKAROS家族锌指2(IKZF2)依赖性疾病或障碍的治疗或预防中或者在减少IKZF2或IKZF4蛋白水平可改善疾病的情况下，例如在癌症的治疗中，使用此类组合和组合物的方法。