CaO2/MnFe2O4 nano composite material as well as preparation method and application thereof

• Main Authors: ZHAO XING, GUAN SHAOQI, LU JIE, WANG XINGYAN, ZHU TONGHE, LIU XIJIAN, WANG JINXIA, CAO DONGMIAO, WANG XIANG, ZHANG ZIWEN
• Format: Patent
• Language: Chinese; English
• Published: 13.08.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention discloses a CaO2/MnFe2O4 nano composite material as well as a preparation method and application thereof. The preparation method of the nano composite material comprises the following steps preparing PEG modified CaO2 nano particles by taking CaCl2 as a raw material through a one-step method; preparing MnFe2O4 nano particles by taking Fe(acac)3 and Mn(acac)2 as raw materials; and taking an ethanol dispersion liquid of the CaO2 nano particles, dropwise adding the ethanol dispersion liquid of the MnFe2O4 nano particles, and carrying out ultrasonic stirring to obtain the CaO2/MnFe2O4 nano composite material. The composite material not only can be used for synergistically treating cancers by integrating an ion interference method and chemical kinetic treatment, but also can be used as a contrast agent of MRI to realize integration of diagnosis and treatment; and meanwhile, the composite material has the characteristics of pH response degradation and magnetic targeting, can be metabolized out of a bo