PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE

The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which...

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Main Authors DAHMEN THOMAS, SONG LICHENG, SCHEIPERS CLAUDIA, CLEATOR EDWARD, CHASSAING CHRISTOPHE PIERRE ALAIN, XIAO WENSONG, SCHMIDT HEIDEMARIE, YIN JINGJUN, SALANTA DANIEL
Format Patent
LanguageChinese
English
Published 06.08.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) combination of these intermediates into compound (I). 本申请涉及一种制备1-[(3R,4S)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺(I)的方法，其中包括(i)合成溴和碘吡啶中间体，(ii)合成可以以对映体纯形式获得的吡唑酯中间体和(iii)组合这些中间体形成化合物(I)。
Bibliography:Application Number: CN20198082538