Improved process for preparing 4,6-dihydroxypyrimidine

The method relates to a process for preparing 4,6-dihydroxypyrimidine by reacting malonic acid esters of formula (II) with a formic acid derivative of formula (III) in the presence of an alkaline metal alcoholate of formula (I) at an elevated temperature. The condensation product formed in this way...

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Bibliographic Details
Main Authors KRAHWINKEL RALF, GROSSMANN ANDRE
Format Patent
LanguageChinese
English
Published 06.08.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The method relates to a process for preparing 4,6-dihydroxypyrimidine by reacting malonic acid esters of formula (II) with a formic acid derivative of formula (III) in the presence of an alkaline metal alcoholate of formula (I) at an elevated temperature. The condensation product formed in this way is crystallized after having been brought into contact with acid. After phase separation and distillation, the alcohol of formula (V) is recovered from the two-phase filtrate resulting from this process, which alcohol can be used for preparing the alkaline metal alcoholate of formula (I). 本发明涉及一种用于通过使式(II)的丙二酸酯与式(III)的蚁酸衍生物在式(I)的碱金属醇化物存在的情况下在提高的温度下反应来制备4,6-二羟基嘧啶的方法。如此形成的缩合产物在与酸进行接触之后结晶。在相分离并蒸馏之后，从此方法产生的两相滤液中回收式(V)的醇，该醇可以用于制备式(I)的碱金属醇化物。
Bibliography:Application Number: CN201980085717