DNA-CELL CONJUGATES

• Main Authors: BERTOZZI CAROLYN, CHANDRA RAVI, ONOUE HIROAKI, TORIELLO NICHOLAS, TWITE AMY, MATHIES RICHARD, DOUGLAS ERIK, HSIAO SHIHIA, FRANCIS MATTHEW B
• Format: Patent
• Language: Chinese; English
• Published: 30.07.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors. 本发明通过将DNA与细胞表面上天然官能团相连接提供DNA和细胞的缀合物。所述细胞可以有或没有细胞壁。所述经修饰的细胞可与基底表面连接，以及可在测定或生物反应器中使用。