Whole-process targeting molecule and application thereof in construction of drug delivery system
The invention belongs to the field of pharmacy, and relates to a whole-process targeting molecule, in particular to a whole-process targeting molecule capable of targeting brain capillary endothelial cells (cross-blood-brain barrier), tumor neovascular endothelial cells (cross-blood-tumor barrier),...
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Main Authors | , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
27.07.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The invention belongs to the field of pharmacy, and relates to a whole-process targeting molecule, in particular to a whole-process targeting molecule capable of targeting brain capillary endothelial cells (cross-blood-brain barrier), tumor neovascular endothelial cells (cross-blood-tumor barrier), tumor mimicry vessels, tumor cells and tumor stem cells, and an application of the modified drug compound and the drug carrying system in tumor diagnosis and targeted therapy. According to the whole-process targeting molecule and the drug loading system constructed by the whole-process targeting molecule, the carried imaging molecule, the treatment drug and the nano drug loading system can be delivered to tumor tissues in the brain in a targeting manner, or can be delivered to peripheral tumor tissues with brain metastasis characteristics in a targeting manner, so that the tumor diagnosis and treatment effects are remarkably improved. The whole-process targeting molecule can mediate imaging molecules, therapeutic d |
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Bibliography: | Application Number: CN202011548622 |