PRE-SURGICAL RISK STRATIFICATION BASED ON PDE4D7 AND DHX9 EXPRESSION

• Main Authors: BAILLIE GEORGE, HOFFMANN RALF DIETER
• Format: Patent
• Language: Chinese; English
• Published: 23.07.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The invention relates to a method of pre-surgical risk stratification of a prostate cancer subject. The method comprises determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in a biological sample obtained from the subject, determining a gene expression profile for DExH-box helicase 9 (DHX9) in the same or another biological sample obtained from the subject, and determining a pre-surgical prognostic risk score for the subject based on the gene expression profile for PDE4D7 and the gene expression profile for DHX9, which may allow for an improved stratification of the subject in a pre-surgical setting that may result in better primary treatment decisions. For instance, the pre-surgical prognostic risk score may allow to make better recommendations on whether to select active surveillance vs. active intervention, e.g., radical prostatectomy, for certain sub-populations of prostate cancer patients. 本发明涉及前列腺癌对象的术前风险分层的方法，包含确定得自所述对象的生物学样品中磷酸二酯酶4D变体7(PDE4D7)的基因表达谱，确定得自所述对象的相同或另一生物学样品中DE