NEW IMMUNOCYTOKINES FOR TREATMENT OF CANCER

The present invention relates to new immunocytokines which are useful for the treatment of cancer. These fusion proteins comprise (i) an antibody or antigen-binding fragment thereof fused to (ii) a cleavable peptide linker, and (iii) cytokine, or functional fragments thereof. Methods of treatment us...

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Bibliographic Details
Main Authors LOWE PETER, CONTET ALICIA, JANIN-BUSSAT MARIE-CLAIRE, AKLA BARBARA, HAEUW JEAN-FRANCOIS, BERTAUX CELINE
Format Patent
LanguageChinese
English
Published 23.07.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to new immunocytokines which are useful for the treatment of cancer. These fusion proteins comprise (i) an antibody or antigen-binding fragment thereof fused to (ii) a cleavable peptide linker, and (iii) cytokine, or functional fragments thereof. Methods of treatment using these immunocytokines are also disclosed. 本发明涉及可用于治疗癌症的新型免疫细胞因子。这些融合蛋白包含(i)抗体或其抗原结合片段，与(ii)可裂解肽连接子及(iii)细胞因子或其功能片段融合。同时公开了使用所述免疫细胞因子的治疗方法。
Bibliography:Application Number: CN201980076617