COLONIC DRUG DELIVERY FORMULATION

A delayed release drug formulation for oral administration to deliver a drug to the colon of a subject. The formulation comprises a core comprising and drug and coating for the core. The coating comprises an outer layer and an inner layer. The outer layer comprises a film- forming enteric polymer ha...

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Bibliographic Details
Main Authors BRAVO GONZALEZ ROBERTO CARLOS, VARUM FELIPE
Format Patent
LanguageChinese
English
Published 23.07.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A delayed release drug formulation for oral administration to deliver a drug to the colon of a subject. The formulation comprises a core comprising and drug and coating for the core. The coating comprises an outer layer and an inner layer. The outer layer comprises a film- forming enteric polymer having a pH threshold at about pH 6 or above and the inner layer comprises a film-forming non-ionic polymer that is soluble in intestinal or gastrointestinal fluid, and a buffer agent in an amount from more than 20 wt % to about 60 wt %, based on the dry weight of the non-ionic polymer. 本发明涉及用于口服给药以将药物递送至受试者的结肠的延迟释放药物制剂。所述制剂包括含有药物的核心和用于所述核心的包衣。所述包衣包括外层和内层。所述外层包括具有约pH值为6以上的pH阈值的成膜用肠溶聚合物，并且所述内层包括可溶于小肠液或胃肠液的成膜用非离子聚合物和缓冲剂，基于所述非离子聚合物的干重，所述缓冲剂的量为大于20wt％至约60wt％。
Bibliography:Application Number: CN201980081059