Preparation method of taste-masking slow-release tilmicosin premix
The invention discloses a preparation method of a taste-masking slow-release tilmicosin premix, which comprises the following steps: a, obtaining raw materials including tilmicosin, a carrier material, a coating slow-release material, a corrigent and a tissue improver for later use; b, uniformly mix...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
23.07.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a preparation method of a taste-masking slow-release tilmicosin premix, which comprises the following steps: a, obtaining raw materials including tilmicosin, a carrier material, a coating slow-release material, a corrigent and a tissue improver for later use; b, uniformly mixing the tilmicosin, the carrier material and the corrigent, firstly wetting with water in an extruder, extruding and granulating, further performing shot blasting and shaping through a shot blasting machine to prepare pellets, and controlling the water content of the pellets within 5%; and c, heating and melting the inner-layer coating sustained-release agent, adding the tissue improver to prepare an inner-layer coating solution, and keeping the temperature at 80-85 DEG C. The tilmicosin premix disclosed by the invention is prepared through a double-layer coating slow-release taste-masking and corrective technology to achieve a good masking effect on the bitter taste of tilmicosin, meanwhile, the tilmicosin premix |
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Bibliography: | Application Number: CN202110003896 |