Preparation method of sulfydryl alkenyl ester compound

The invention relates to a preparation method of a sulfydryl alkenyl ester compound, belongs to the field of organic chemical synthesis, and aims to solve the problems of high risk of large-scale production and the like, and the synthesis route provided by the invention comprises the following three...

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Bibliographic Details
Main Authors ZHOU ZHANGTAO, YE WEIPING, XIE XINXIN, WANG YANG, FEI ANJIE
Format Patent
LanguageChinese
English
Published 20.07.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a preparation method of a sulfydryl alkenyl ester compound, belongs to the field of organic chemical synthesis, and aims to solve the problems of high risk of large-scale production and the like, and the synthesis route provided by the invention comprises the following three steps: (1) carrying out a reaction on a starting material ethyl 2-oxo carboxylate compound and Tf2O (trifluoromethanesulfonic anhydride) under the action of alkali and a solvent A, so as to generate an enol intermediate 1 protected by trifluoromethanesulfonyl; (2) carrying out substitution reaction with a sulfo reagent to obtain an intermediate 2; and (3) performing deprotection on the intermediate 2 under the action of a deprotection reagent to obtain a target product 3. The method for preparing the sulfydryl alkenyl ester compound has the beneficial effects that the process is novel, toxic gases such as hydrogen sulfide are prevented from being used, the overall safety and environmental protection property of th
Bibliography:Application Number: CN202110453696