Method for preparing eltrombopag nitration intermediate in micro-channel continuous flow reactor

• Main Authors: ZHOU ZHANGTAO, YE WEIPING, WU GUIBAO, FEI ANJIE, ZENG YANGTONG
• Format: Patent
• Language: Chinese; English
• Published: 13.07.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a method for preparing an eltrombopag nitration intermediate in a micro-channel continuous flow reactor, belongs to the field of organic chemical synthesis, and aims to improve the high-risk nitration process involved in the eltrombopag raw material medicine production process and inevitable nitration reaction. Two reaction materials are respectively injected into a micro-channel at a certain flow rate; and the mixed and reacted material is injected into a quenching kettle, and after quenching is completed, centrifuging, washing and drying to obtain a target product. The method for preparing the eltrombopag nitration intermediate in the micro-channel continuous flow reactor has the beneficial effects that a novel process technology is adopted, and the method has the characteristics of safety, high efficiency, environment friendliness and the like. 一种在微通道连续流反应器中制备艾曲波帕硝化中间体的方法，本发明属于有机化学合成领域，为改善艾曲波帕原料药生产过程中涉及高风险硝化工艺过程，且又无法避免此硝化反应，本发明将两种反应物料分别以一定流速注入微通道，混合反应后的物料再注入淬灭釜中，完成淬灭后，再离心、洗涤和干燥得到目标产