Preparation method of 4-cyano-5-bromopyrimidine

The invention discloses a preparation method of 4-cyano-5-bromopyrimidine, the preparation method comprises the following steps: taking 4-chloro-5-bromopyrimidine (compound II) as a raw material, and carrying out bromine chlorine substitution reaction on the 4-chloro-5-bromopyrimidine (compound II)...

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Bibliographic Details
Main Authors YANG GUANGCHAO, ZHANG HONGFEI, YU SHANBAO
Format Patent
LanguageChinese
English
Published 09.07.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a preparation method of 4-cyano-5-bromopyrimidine, the preparation method comprises the following steps: taking 4-chloro-5-bromopyrimidine (compound II) as a raw material, and carrying out bromine chlorine substitution reaction on the 4-chloro-5-bromopyrimidine (compound II) and trimethylbromosilane to generate 4, 5-dibromopyrimidine (compound III); the compound III and cuprous cyanide are subjected to a nucleophilic substitution reaction to generate 4-cyano-5-bromopyrimidine (compound I), and the yield of the two-step reaction can reach 70% or above. 本发明公开了一种4-氰基-5-溴嘧啶的制备方法，包括以下步骤：以4-氯-5-溴嘧啶(化合物II)为原料，与三甲基溴硅烷发生溴氯取代反应生成4、5-二溴嘧啶(化合物III)；化合物III与氰化亚铜经过亲核取代反应生成4-氰基-5-溴嘧啶(化合物I)，两步反应收率可以达到70％以上。
Bibliography:Application Number: CN201911337081