Prediction method and device for tumor neoantigen load

• Main Authors: SU XIAOFAN, JIN HAOXUAN, GAO ZHIBO, WANG JIAQIAN
• Format: Patent
• Language: Chinese; English
• Published: 29.06.2021
• Subjects: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

The invention discloses a method and a device for predicting tumor neoantigen load, and provides a specific method for predicting tumor neoantigen load degree based on a tumor immune editing theory. The specific numerical value of the tumor neoantigen load predicted based on the tumor immune editing theory is estimated by fully utilizing each mutation site of a tumor tissue sample and the potential tumor neoantigen, and a numerical reference basis is provided for subsequent prediction of the immunotherapy curative effect. According to the method, the tumor neoantigen load can be accurately quantified, and the tumor neoantigen load can be used as a biomarker to predict the curative effect of an immune checkpoint inhibitor anti-PD-(L)1. 本发明公开了一种肿瘤新生抗原负荷的预测方法及装置，提供了一种基于肿瘤免疫编辑理论的预测肿瘤新生抗原负荷程度的具体方法，充分利用肿瘤组织样本各突变位点和潜在肿瘤新生抗原估算出对应基于肿瘤免疫编辑理论预测的肿瘤新生抗原负荷的具体数值，为后续预测免疫治疗疗效提供了一个数值上可以参考的依据。该方法可准确量化肿瘤新生抗原负荷，并且能够作为生物标志物对免疫检查点抑制剂anti-PD-(L)1的疗效进行预测。