Cyclic peptide compound as well as preparation method and application thereof

• Main Authors: WANG JUNFENG, LONG JIEYI, LIU YONGHONG, ZHOU XUEFENG, LIN XIUPING, PANG XIAOYAN, YANG BIN, LIAO SHENGRONG
• Format: Patent
• Language: Chinese; English
• Published: 25.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses a cyclic peptide compound as well as a preparation method and application thereof. According to the invention, four new cyclic peptide compounds (compounds 1-4) are separated and purified from a fermentation culture of Aspergillus sp.H6-7, and the structural formulas of the compounds are respectively shown as a formula (I), a formula (II), a formula (III) and a formula (IV). The compound 4 is a depsipeptide compound, has remarkable nasopharynx cancer resisting activity and acetylcholin esterase inhibiting activity, and can be used for developing nasopharynx cancer resisting drugs and acetylcholin esterase inhibitor lead compounds, so that alternative compounds are provided for innovative development of anti-cancer drugs and acetylcholin esterase inhibitors. The important significance is realized on the development of Chinese marine drug resources. 本发明公开了一类环肽类化合物及其制备方法和应用。本发明从曲霉菌Aspergillus sp.H6-7的发酵培养物中分离纯化得到4个新的环肽类化合物(化合物1-4)，其结构式分别如式(I)、式(II)、式(III)和式(IV)所示。其中，化合物4为缩酚酸肽类化合物，具有显著的抗鼻咽