PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof

• Main Authors: MICHAEL DOWNES, SUNIL KUMAR PANIGRAHI, SUSANTA SAMAJDAR, KRUGER ALBERT, TAKAHASHI TAISUKE, LAGU BHARAT, MICHAEL PATANE, EVANS RONALD M, RAMESH SENAIAR, MIURA MASANORI
• Format: Patent
• Language: Chinese; English
• Published: 25.06.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are compounds I, II, or III and compositions for increasing PPAR delta activity. The compounds and compositions provided herein are useful for the treatment of PPAR delta related diseases (e.g., muscle diseases, vascular diseases, demyelinating diseases, and metabolic diseases). 本文提供了用于增加PPARδ活性的化合物I、II或III以及组合物。本文提供的化合物和组合物可用于治疗PPARδ相关疾病(例如肌肉疾病、血管疾病、脱髓鞘疾病和代谢性疾病)。