DIRECT DE-DIFFERENTIATION OF URINE CELL INTO NUERAL STEM CELL USING SYNTHETIC MESSENGER RNA

• Main Authors: YOU SEUNG-KWON, HONG WON JUN, PARK JEONG-HYUN, SON DA RYEON, PARK GYU MAN, KIM IN YONG, GAO WEI WEI, JUN EUN KYOUNG, JANG JI HOON, KANG PHIL JUN, YOON BYUNG-SUN, LEE JANG BO, ZHENG JIE, YUN WON JIN
• Format: Patent
• Language: Chinese; English
• Published: 22.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a method for inducing a de-differentiation of neural stem cells from urine cells by introducing mRNAs of de-differentiation factors Oct4, Sox2, Klf4, and Glis1; and a composition for the prevention or treatment of neurological damage diseases comprising the neural stem cells induced by the method as an active ingredient. 本发明涉及通过引入去分化因子Oct4、Sox2、Klf4和Glis1的mRNA从尿细胞诱导神经干细胞去分化的方法；以及用于预防或治疗神经损伤疾病的组合物，该组合物包含作为有效成分的通过该方法诱导的神经干细胞。