METHODS AND COMPOSITIONS FOR TREATING CANCER USING MRNA THERAPEUTICS

• Main Authors: FREDERICK JESSE, BAI AILIN, GURUMURTHY SUSHMA, MISHRA ASHISH
• Format: Patent
• Language: Chinese; English
• Published: 22.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

The disclosure features methods for treating cancer, including solid tumors and disseminated cancers such as myeloid malignancies, using one or more mRNAs encoding an OX40L polypeptide, an IL-12 polypeptide, an IL-15 polypeptide, and combinations thereof. 本公开的特征在于使用编码OX40L多肽、IL-12多肽、IL-15多肽以及它们的组合的一种或多种mRNA来治疗癌症的方法，所述癌症包括实体瘤和播散性癌症，如髓系恶性肿瘤。