包含来源于决明子芽的萘并吡喃酮衍生物的神经细胞保护用组合物

• Format: Patent
• Language: Chinese
• Published: 07.02.2025
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

本发明涉及萘并吡喃酮衍生物及将包含其的决明子芽提取物作为有效成分包含的组合物。根据本发明的一个方面的组合物具有抗氧化效果、以及保护神经细胞免受氧化应激或者抑制神经细胞死亡的效果，特别是，具有抑制由于谷氨酸毒性导致的视网膜神经细胞或海马神经细胞的损伤或死亡的效果，因此可以作为用于由视神经损伤导致的视力下降和减退以及眼部疾病的治疗或预防、由于脑神经损伤导致的记忆力减退、学习能力减退、抑郁症发作及恶化和退行性脑神经疾病的治疗或预防的药物组合物使用。 The present invention relates to a naphthopyrone derivative and a composition comprising, as an active ingredient, a Cassia obtusifolia shoot extract including the naphthopyrone derivative. A composition according to an aspect of the present invention has an antioxidative effect and an effect of protecting neurons from oxidative stress or inhibiting the death of neurons, and in particular, has an effect of inhibiting damage or death of retinal neurons or hippocampal neurons due to glutamate toxicity, and thus the composition can be used as a pharmaceutical or food composition for the treatment or prevention of eye diseases and deterioration and loss of vision caused by optic nerve injury, and for the treatment or prevention memory loss, decline in learning ability, onset and worsening of d